Functional analysis of genetic polymorphisms
نویسندگان
چکیده
منابع مشابه
Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms.
BACKGROUND Expression of the Helicobacter pylori outer membrane protein HopH is regulated by phase variation within a CT dinucleotide repeat motif of the hopH gene. METHODS To investigate the importance of HopH for bacterial pathogenicity, we performed a detailed functional genomic and population-based genetic characterization of this contingency locus. RESULTS Sequencing of hopH in H. pylo...
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Glucocorticoids are widely used as potent anti-inflammatory drugs. Glucocorticoids exert their pharmacological effects by binding to a glucocorticoid receptor (GR), which promotes expression of its target genes or suppresses transcription mediated by other transcriptional factors, such as nuclear factor-kappaB (NF-kappaB). To identify genetic polymorphisms affecting glucocorticoid responses, th...
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BACKGROUND Endometriosis has a strong genetic component, and numerous genetic studies have been reported. METHODS We have systematically reviewed these studies and included 114 in our final selection. RESULTS We found no consistent evidence linking endometriosis with specific polymorphisms in genes encoding inflammatory mediators, proteins involved in sex steroid metabolism, vascular functi...
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in fact, this study focused on the following questions: 1. is there any difference between the effect of functional/notional approach and the structural approaches to language teaching on the proficiency test of efl learners? 2. can a rather innovative language test referred to as "functional test" ge devised so so to measure the proficiency test of efl learners, and thus be as much reliable an...
15 صفحه اولAssociation of genetic polymorphisms with osteosarcoma risk: a meta-analysis.
Osteosarcoma (OS) is the most common pediatric and adult bone malignancy worldwide. Genetic polymorphisms may play critical roles in the development of OS. However, there present inconclusive results. The current study was to investigate the role of genetic polymorphisms in OS risk. Electronic databases were searched for relevant studies published between 2000 and 2014. The odds ratio (OR) with...
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ژورنال
عنوان ژورنال: The Journal of Animal Genetics
سال: 2012
ISSN: 1345-9961,1884-3883
DOI: 10.5924/abgri.40.51